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Recent studies showed that the rate-limiting glycolytic enzymes, pyruvate kinase M2 (PKM2) directly phosphorylates H3 at threonine 11 (H3T11) to regulate gene expression and cell proliferation, revealing its non-metabolic functions in connecting glycolysis and histone modifications. Several diketopiperazines have been shown to promote carbon-carbon coupling between benzene and aryl halides in the presence of potassium tert-butoxide and without the assistance of a transition metal catalyst.

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We have analyzed extracellular matrix(ECM) of a case of pulmonary epithelioid hemangioendothelioma (PEH). Open carpal tunnel release with use of a nasal turbinate speculum.

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T-LBL/ALL predominantly affects children or adolescent males and frequently presents with lymphadenopathy and mediastinal masses, whereas B-LBL/ALL are often accompanied by bone marrow and peripheral blood involvement. Neuron-restrictive silencer factor (NRSF) and its isoforms are differentially regulated in rodent models of self-sustaining status epilepticus (SSSE). Larval dispersal modeling of pearl oyster Pinctada margaritifera following realistic environmental and biological forcing in Ahe atoll lagoon. To describe the perception of general health in a sample of grown-up congenital heart disease (GUCH) patients who are no longer in medical follow-up and to determine whether patients feel affected in daily life because of their heart disease.

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In total, 12 538 men aged 40 to 59 years were enrolled in 1993 and followed up through 2011. Outcome evaluation of 10,317 laparoscopic cholecystectomies: a 17-year experience at a single center. The risk factors for such complications include obesity, prolonged operative time, and positioning in the lateral decubitus position.

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To investigate the inhibitory effects of sinomenine (SIN) combined with 5-fluorouracil (5-FU) on esophageal carcinoma in vitro and in vivo. Evolutionary algorithms (EAs) provide a potentially powerful approach for exploring multidimensional stimulus spaces based on real-time spike feedback, but two important issues arise in their application. Compared with the lean controls, obese Zucker rats showed significant glomerular matrix expansion and increased mRNA expression of the extracellular matrix protein fibronectin, inflammatory mediators interleukin-6 and monocyte chemoattractant protein-1, and 2 major enzymes of arachidonate metabolism, namely, 12/15-lipoxygenase and cyclooxygenase-2. A systematic approach to the various common aesthetic problems of the lower lateral cartilages is presented.

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Hearing tests were performed using a tape recorder with various speech control systems in a soundproof room. An analysis of usability aspects and accuracy for three different methods of neurosurgical intervention-stereotaxy, neuro-navigation, and robotic assistance-was accomplished in a detailed study including clinicians with different experience levels. Newer drugs can be culpable for CADRs, and more CADRs are now documented with increased severity at clinical presentation. Phase II study of platinum and mitoxantrone in metastatic prostate cancer: a Southwest Oncology Group Study.

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To assess and establish the utility of radionuclide salivagram in the routine evaluation of developmentally normal children with persistent/recurrent lower respiratory tract infection. Consequently, the potential translational value of AT1 inhibition in clinical AAA disease management remains incompletely understood on the basis of the existing literature. Single-particle tracking (SPT) has emerged as a powerful way to directly visualize these movements.

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TVT-Exact and midurethral sling (SLING-IUFT) operative procedures: a randomized study. In each cell, early replicating genomic regions are alternated to late-replicating regions. To evaluate the outcome of peniscopically controlled laser excision of early-stage penile carcinoma. Differences Among Angiotensin II Type 1 Receptor Blockers: Characteristics of Candesartan Cilexetil.

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Experimental diabetes mellitus in young adult Lewis rats was successfully treated by transplantation of fetal pancreases from syngeneic fetuses. The 247-260 and 289-299 alpha-helices of Bacillus subtilis neutral protease have a lysine in their N-terminal turn. Although many countries have already addressed the burden of FH by means of national registries, Turkey has no national FH registry or national screening program to detect FH. While apoptotic and necrotic cells differ biochemically, both are cleared by macrophages for elimination. We create structured landscapes in which we specify the amount of habitat and degree of fragmentation and ask how landscape structure, dispersal strategy, and scale affect the presence of alternative stable states, or bistability.

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Establishing linear solvation energy relationships between VOCs and monolayer-protected gold nanoclusters using quartz crystal microbalance. However, such methods need to fulfill the principles of analytical validation to determine their suitability to assess nucleotide polymorphisms in target genes. Dehydroabietylamine derivatives might be a new class of multi-targeted and effective PTK inhibitors with structure modifications. Automatic analysis of altered gait in arylsulphatase A-deficient mice in the open field. Proteomics data also clearly demonstrate the absence of oxidative stress and indicate that the primary mechanism of cell death is related to the cell membrane damage, which does not appear to be due to lipid peroxidation.

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Eighty-eight percent of bucket drownings occurred in toddlers aged 7 to 15 months old. Individuals with T2DM may be at higher risk of developing periodontal disease. Six-year study shows a 15-fold increase in certain lumbar surgery procedures. The mechanism responsible for other types of rare fragile sites, i.e., distamycin A-inducible and BrdU-requiring, is unknown, although cytogenetic studies suggested that these fragile sites play a mechanistic role in breakage and recombination and may also be integration and modification sites of foreign viral DNA genomes.

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The myocardial infarct size-limiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA. Unlike the highly homologous betaine-homocysteine methyltransferase (BHMT), BHMT-2 cannot use betaine.

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The aim of this study was to determine how the risks of predation and heat stress influenced their behavior while feeding on a key food, fruit of the baobab tree (Adansonia digitata). The impact of dynamic MR on long-term mortality, hospital admission for heart failure, and major adverse cardiac events has never been investigated.

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With the advent of plasmid-based approaches to generate recombinant VSV viruses that express glycoproteins of other viruses, researchers now have the means to generate vaccine candidates targeting a variety of human pathogens. Mixed urinary incontinence (MUI), defined as mixed symptoms of stress urinary incontinence (SUI) and overactive bladder (OAB), is a difficult entity if conservative treatment has failed. The other antifungals, belonging to the polyene and azole classes, are used off-label in treating ocular infections and are administered topically, orally, intraocularly, or systemically. Analysis of serum-mediated immunosuppression in normal pregnancy, abortion and contraception.

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We report on an in-situ observation of the colloidal silver nanoparticle self-assembly into a close-packed monolayer at the air/water interface followed by a 2D to 3D transition. Extensive simulation results have clearly demonstrated the superior performance accomplished by the proposed digraph approach, compared with those of using the undirected graph approach.

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The methodological quality of included studies was assessed individually by two review authors. Coronary artery aneurysms by noncontrast electron beam tomography. Since 1995, the modified Alfieri technique with a tailed, expanded, polytetrafluoroethylene tube as a bridging strip was the procedure for repair and 27 patients underwent the procedure. The standard localized therapies for prostate cancer include external-beam radiation therapy, brachytherapy and radical prostatectomy. Dual incarcerated internal hernias after laparoscopic total gastrectomy with Roux-en-Y reconstruction for gastric cancer.

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Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence. A B-cell line, derived from PTLD tissue and clonally related to the parent lesion, was tested for its response to IFN-alpha in vitro.

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Few data exist on the long-term outcome of postnatally acquired HCMV infection via breast milk. Inhibition of Pseudomonas aeruginosa ExsA DNA-Binding Activity by N-Hydroxybenzimidazoles. Adipose tissue-derived stem cells (ADSCs) can be easily obtained from subcutaneous adipose tissue, and ADSCs can be demonstrated to display multilineage developmental plasticity.

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Glucose abnormality and diabetes are the most common comorbidities in cystic fibrosis (CF). The genetic subtypes based on the phylogeny of env sequences are not classical neutralization serotypes.

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The present study provides evidence for subclinical enthesitis at the level of the DIP joint in patients with nail psoriasis. The effect of allograft storage on in vivo repair outcomes was determined for OCA transplanted into 15 recipient goats and analyzed at 12 months.

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Evaluation of the Safety and Tolerability of Conjunctival Ring for Posterior Segment of the Eye. The magnitude and frequency of ERD were compared between groups for characterization of ALS specific changes. Engineered nucleases that cleave specific DNA sequences in vivo are valuable reagents for targeted mutagenesis.

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Bisphenol A: An environmental factor implicated in renal vascular damage. Fifty-eight patients underwent anterior anorectotomy for removal of intrarectal tumor. Pyridazine N-Oxides as Precursors of Metallocarbenes: Rhodium-Catalyzed Transannulation with Pyrroles. Purification and characterization of isoaccepting species of phenylalanyl-transfer ribonucleic acid from rat liver.

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It is suggested that the native molecule of epiglycanin of molecular weight 500,000 contains more than 500 carbohydrate chains attached to a single polypeptide chain of similar to 1,300 amino acid units. Three Complementary Approaches to Characterize Buprenorphine Misuse. Using a lncRNA microarray, we identified a novel lncRNA, uc.134, whose expression was significantly decreased in the highly aggressive HCC cell line HCCLM3 compared with MHCC97L cells.

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Blood rheology, in particular, the shear-rate dependent de-aggregation of red blood cell (RBC) clusters and the transport of deformable cells, are modeled. After their previous experience was determined, each participant was videotaped inserting a USG CVC in the right internal jugular vein on models. In all, 12 patients had major complications of corticosteroid therapy. A 60-year-old woman presented with respiratory insufficiency following cytoreductive surgery and intra-abdominal hyperthermic chemotherapy performed for pseudomyxoma intraperitonei. Information regarding caregiver appraisal of caregiving situations, difficulties with care provision, and ways of dealing with stressors were obtained.

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Incident reporting systems have been identified as the primary method to capture medical error and harm. Effect of isoserum transfusion on the morphofunctional activity of the mast cells in experimental burn disease In conclusion, it must be kept in mind that acute disseminated encephalomyelitis can rarely present with biparieto-occipital involvement which extends to corpus callosum and can mimic adrenoleukodystrophy.

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Prevalence of retinitis pigmentosa and allied disorders in Denmark. Upon entering the stomach, intestinal tract, blood and tissue fluids, poly-alpha,beta-DL-aspartyl-L-alanine assembled to small nanoparticles or nanoblocks to escape the entrapment by macrophages and exhibited desirable thrombolytic action.

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Thus, orlistat may be preferred in the obese hypertensive patients. To evaluate the efficacy of combined positron emission tomography-computed tomography (PET-CT) in identifying salivary gland malignancies and to examine the role of PET-CT in the management of these patients. Pediatric patients who undergo cardiopulmonary bypass are at risk for poor cardiac, pulmonary, and renal outcomes.

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Development, Validation, and Assessment of an Ischemic Stroke or Transient Ischemic Attack-Specific Prediction Tool for Obstructive Sleep Apnea. Two large, well-circumscribed nodules were entirely composed of biphasic, piloid, astroglial patterns that corresponded strictly to a pilocytic astrocytoma. All non-colloidal markers exhibited a tendency for adsorption onto solid phase. Incidence and variables predicting Gleason score up-grading between trans-rectal ultrasound-guided prostate biopsies and radical prostatectomy. Alpha2-adrenergic control of dopamine overflow and metabolism in mouse striatum.

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Perikaryal growth and the growth and maturation of the dendritic tree of relay neurons are synchronous. A Medline literature search was performed to elucidate all relevant studies of nanotechnology with specific attention to its application in urology. The forced rupture of single chemical bonds under external load is addressed.

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Analyses of binding characteristics determined that both YbaB orthologs bind as homodimers. Therapeutic and prognostic course in patients with suspected lung cancer. Going to the doctors: the views of mothers of children with recurrent abdominal pain. We successfully performed aneurysmorrhaphy and her postoperative course was uneventful. Plasma MMP-3 was measured at 0-12, 12-24 h and for subsequent 24 h periods during admission.

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Patient education and consumer medicine information: a study of provision by Queensland rural and remote area Registered Nurses. Stimulation of efferents alters the cochlear microphonic and the sound-induced resistance changes measured in scale media of the guinea pig. The synthesized phycocyanin variant, designated as HPY, bound one heme per protein molecule and showed spectroscopic features characteristic of six-coordinated heme proteins.

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Both medication lists were manually screened for potential drug-drug interactions by using several information sources on interactions, e.g. There was a statistical difference in surface roughness of orthodontic archwires among the brands studied.

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Clinical review by a neurologist, International RLS Rating Scale (IRLSRS) score, and changes in IRLSRS score after pergolide treatment. These results indicate that the electrostatic interaction between the insulin and the membranes played an important role in the insulin adsorption.

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We demonstrated the expression of alpha-smooth muscle actin, smooth muscle myosin, calponin, caldesmon, and caveolin in epithelioid cells of rabbit ear and in human toes, finger tips, and glomus tumors by means of indirect immunofluorescence techniques and immunoelectron microscopy. On average, for the high impact journal articles published in 2003, over a third could be located at non-journal websites. Basic statistical evaluation of the data resembled high degree of inverse correlations between PCDD/F concentrations and UV and solar radiation.

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albicans and against specific bacteria, fungi, and a trichomonad. 68Ga-Dotanoc and 99mTc-HYNICTOC scans confirmed the intrarenal mass to be of neuroendocrine origin. Neutrophil gelatinase-associated lipocalin was measured in feces from 73 patients with IBD, 21 patients with infectious enterocolitis, 21 patients with irritable bowel syndrome, and 23 healthy subjects using ELISA. Recently, many virtual reality and robotics applications have been called on to create virtual environments from real scenes. Seventeen patients were seen by a neurologist for diagnosis of temper tantrums.

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Therefore, it can be concluded that these two cilostazol tablet formulations were considered bioequivalent. Multidetector computed tomography (MDCT), which has been mainly used to study coronary atherosclerosis, also enables non-invasive measurement of carotid and aortic atherosclerosis and might be suitable for screening in the general population. Eighty sons of women with PCOS (PCOS(S)) and 56 sons of control women without hyperandrogenism (C(S)), matched for age, were studied. Pulmonary fissure differs among patients, but the relationship between pulmonary fissure development and survival in patients with resected lung adenocarcinoma has not been evaluated.