Combutol is a bactericidal drug that is rapidly and well absorbed in the gut, with peak serum levels occurring 2 hours after a dose. It is then rapidly excreted in urine. The most important complication of Combutol therapy is retrobulbar neuritis manifested by impaired visual acuity, color blindness and restricted visual fields. Except in patients with pre-existing ophthalmic disease, optic neuritis is extremely rare when Combutol is used at standard doses (15 mg/kg). Patients can be assessed by an ophthalmologist prior to starting treatment but lack of this facility should not prevent use of Combutol. Patients should be warned to report symptoms of visual change immediately and Combutol should generally be avoided in children.
Other names for this medication:
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