Combivir (Zidovudine-lamivudine) is a nucleoside reverse transcriptase inhibitor (NRTI) combination tablet that was used as the backbone component of combination antiretroviral therapy for years, but now is rarely used due to short-term and long-term toxicity from the zidovudine component. Lamivudine is usually well-tolerated. Zidovudine, however, frequently causes gastrointestinal side effects, headache, and malaise. Patients taking zidovudine for a prolonged period can develop neutropenia, anemia, myopathy, lactic acidosis, lipoatrophy, and hepatomegaly with steatosis. In addition, the zidovudine-lamivudine combination requires twice-daily dosing. Persons who currently take zidovudine-lamivudine should be strongly encouraged to change to a recommended agent, unless there is a clear indication for zidovudine based on resistance mutations with no alternative options.
Other names for this medication:
Combivir,
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Rats having received drinking metronidazole side effects respiratory water enriched with zinc (zinc acetate, 22.8 mmol/l) developed significantly more pulmonal metastases after an i.v. Does carotid-ankle vascular index reflect proper vascular distensibility in hemodialysis patients?
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