Tenutex is a drug used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Tenutex works by inhibiting the enzyme acetaldehyde dehydrogenase, causing many of the effects of a hangover to be felt immediately following alcohol consumption. Tenutex plus alcohol, even small amounts, produce flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, fast heart rate, low blood pressure, fainting, marked uneasiness, weakness, vertigo, blurred vision, and confusion. In severe reactions there may be respiratory depression, cardiovascular collapse, abnormal heart rhythms, heart attack, acute congestive heart failure, unconsciousness, convulsions, and death.In the body, alcohol is converted to acetaldehyde, which is then broken down by acetaldehyde dehydrogenase. When dehydrogenase enzyme is inhibited, acetaldehyde builds up, causing the unpleasant effects. Tenutex should be used in conjunction with counseling and support. Tenutex has been studied as a possible treatment for cancer and latent HIV infection.
Other names for this medication:
Disulfiram,
Antabuse,
Anticol,
Aversan,
Esperal,
Etabus,
Tenutex,
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