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Cycloblastin (Cyclophosphamide)

Cycloblastin is used alone or in combination with other medications to treat Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cells that normally fights infection); cutaneous T-cell lymphoma (CTCL, a group of cancers of the immune system that first appear as skin rashes); multiple myeloma (a type of cancer of the bone marrow); and certain types of leukemia (cancer of the white blood cells), including chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute myeloid leukemia (AML, ANLL), and acute lymphoblastic leukemia (ALL). It is also used to treat retinoblastoma (cancer in the eye), neuroblastoma (a cancer that begins in nerve cells and occurs mainly in children), ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed), and breast cancer. Cycloblastin is also used to treat nephrotic syndrome (a disease that is caused by damage to the kidneys) in children whose disease has not improved, has gotten worse, or has come back after taking other medications or in children who experienced intolerable side effects with other medications. Cycloblastin is in a class of medications called alkylating agents. When Cycloblastin is used to treat cancer, it works by slowing or stopping the growth of cancer cells in your body. When Cycloblastin is used to treat nephrotic syndrome, it works by suppressing your body's immune system.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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In the incidental learning condition, the high humor group performed better than the low humor group, but in the intentional learning condition, there was no humor effect. Several themes were identified and organized into categories that range from inter-professional collaboration through to issues of hospital-level resources and the role of relationships between hospitals and external organizations at the provincial level.

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aureus (MRSA) on polystyrene material by inhibiting the expression level of four biofilm formation-related genes in vitro. These data suggest that glutamate and products of its transamination decrease the contraction of hypoxic myocardium stimulating anaerobic energy formation in the tricarboxylic acid cycle. Inhibition of p38alpha/beta MAPKs (a) promotes exit from the cell cycle, (b) prevents differentiation, and (c) insulates the cell from most external stimuli allowing the satellite cell to maintain a quiescent state. However, evidence for a role of ONOO- in vivo is based largely upon detection of 3-nitrotyrosine in injured tissues. Properties and structure of the tobacco mosaic virus strain K2 genome

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Expression of SHYG in shoot tissue is triggered by root flooding and treatment with ET, constituting an intrinsic ET-SHYG-ACO5 activator loop for rapid petiole cell expansion upon waterlogging. Significance of selected clinical and paraclinical findings in the diagnosis of hypernephroid carcinomas

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To determine whether psychosocial stress, in the form of adverse life events and social difficulties, depressive illness, or lack of confiding relationships, shortens the postoperative disease free interval in breast cancer patients. This has implications for estimating the assay window period and in the perspective of incidence estimation from HIV case surveillance. Quetiapine, like all antipsychotics, has anticholinergic effects, including cardiac, psychiatric and digestive disorders. Our results showed that these compounds significantly attenuated H2O2-induced toxicity in PC12 cells in a dose-dependent manner. Standardized photographic documentation was obtained at baseline, and at 2 weeks after treatment.

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A routine electrocardiogram demonstrated acute inferior wall ST-elevation myocardial infarction. All experiment groups were analyzed histologically and immunohistochemically (GFAP, Ki-67, and Pan cadherin) and for motor function after surgery. FT-like genes are differentially expressed, with AcFT1 confined to shoot tip and AcFT2 to mature leaves. Taste acuity in institutionalized and noninstitutionalized elderly men.

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The finding of elevated AC in AML supports the concept that this enzyme represents a novel and realistic therapeutic target for this common leukemia. Small angle neutron scattering studies indicate that the micelles undergo composition dependent uniaxial growth without any significant change in the cross section radius, in the absence of electrolytes. Inhibition of Gremlin alleviated proteinuria and renal collagen IV accumulation 12 weeks after the STZ injection and inhibited renal cell proliferation and apoptosis. The evidence suggests that subclinical vitamin D deficiency does affect bone acquisition, potentially beginning in utero and extending into adolescence.

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A gastric tumor cell line (N87) was labeled for major histocompatibility complex class I heavy chain and beta2-microglobulin with antibodies conjugated with fluorescein- and indocarbocyanine-like fluorophores and analyzed in FCET measurements on a cell-by-cell basis using three flow cytometers: FACSCalibur, FACSDiVa, and FACSArray. Molecular characterization of oncocytic thyroid malignancies for RET/PTC or BRAF genetic alterations may help with (preoperative) classification and prognostic evaluation of these tumors.

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Sharp, local synchrony among putative feed-forward inhibitory interneurons of rabbit somatosensory cortex. In occlusion of the carotid arteries the alpha 2-agonists fail to reduce the degree of cerebral ischemia and hypotension. Based on sequence analysis, this protein has no apparent orthologs outside of the vertebrates. Cr-Si nanorod Schottky diodes with longer nanorods yield higher reverse current than those with shorter nanorods due to the enhanced electric field, which is attributed to a high aspect ratio of Si nanorod.

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Complete fracture patterns varied following bending failure, but incomplete fractures and fracture surface characteristics were observed in all impacted specimens. A pair of stable, well-defined, and quasi-reversible cyclic voltammetric peaks was observed with the formal potential at -276.2 mV (vs. All groups that experienced tailshock stress also had reduced open field activity 24 h later. The incidence of mania peaks in early adult life but there is clear evidence of early and later onset subgroups which may represent different forms of disorder. We have investigated the transient pore dynamics in a chemically destabilized liquid membrane in buffer solutions at macroscopic scale.

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The possibility of variability concerning auditory phenotype should be considered even within family members carrying the same SLC26A4 mutations when providing genetic counseling to multiplex EVA families. Based on individual volumes of 44 brain compartments and structures at baseline and 52 weeks of follow-up, means and standard deviations of annualized percentage volume changes were used to estimate standardized effect sizes and the required sample sizes per group for future 2-armed, placebo-controlled therapeutic trials. Increase in the cytoskeleton of endothelial cells in mesenteric microvessels in experimental traumatic hemorrhagic shock

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Because current evidence on this topic is inconclusive and long-term follow-up data are scarce, we wanted to estimate the effect of antibiotic treatment for a first AOM episode occurring during infancy on AOM recurrences and AOM-related health care utilization later in life. New AP4B1 mutation in an African-American child associated with intellectual disability. Local regulation of corpus luteum development and regression in the cow: Impact of angiogenic and vasoactive factors. Transmission electron microscopy and electron diffraction are used to study the changes in morphology of composite films of poly(3-hexylthiophene) (P3HT) and a methanofullerene derivative (PCBM) in bulk heterojunction solar cells. Isolation and characterization of cyanogen bromide peptides from the collagen of bovine articular cartilage.

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The transcription factor RUNX1 is essential for definitive hematopoiesis and is required for the expression of a number of important hematopoietic regulator genes. Does beta blocker therapy affect the diagnostic accuracy of adenosine single-photon-emission computed tomographic myocardial perfusion imaging? They correlate directly detected single-quantum (1Q) coherences in the t(2) domain with either of 1Q, two-spin 2Q or single-spin multiple-quantum coherence-evolutions in the indirect (t(1)) dimension.

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Attention and eye-movement control in reading: The selective reading paradigm. We attribute the higher incidence of post-irradiation cystic malacia, in our long-term follow-up study, to the cranial irradiation for pediatric brain tumors, particularly supratentorial brain tumors, and recommend a regular, long-term follow-up of brain tumor patients treated with cranial irradiation.

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The effects of SP-IPT and artemether-lumefantrine as curative treatment were also evaluated by assessing the occurrence of peripheral infections or matching genotypes between peripheral and placental parasites following treatment. However, despite the fact that they complemented the synthesis of O antigen in the DeltawbaP mutant in vivo, membrane extracts containing WbaP derivatives without the N-terminal domain failed to transfer radioactive Gal from UDP-Gal into a lipid-rich fraction. The interpretation of repeat renal biopsies in patients with lupus nephritis.

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However, the adjuvant activity of bestatin immunotherapy for these cancers should be further investigated to confirm its activity. Overexpression of Cyclin A1 predicts a lower recurrence rate in HNSCC independently of HPV16. ANXA5 play important role in the migration and apoptosis of CCA cells.

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Since preoperative irradiation produces no significant difference in the operative difficulty or postoperative morbidity, it is assumed that the vascularity of the area has returned to the pre-treatemtn level. These findings in SPD suggest altered fronto-temporal connectivity through the UF, similar to findings in schizophrenia, and intact neocortical-limbic connectivity through the CB, in marked contrast with what has been reported in schizophrenia.

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Studies on the cause of death of the registered TB-patients: with special reference to the relation between pulmonary tuberculosis and the lung cancer. To study the optimal conditions and parameters for the enrichment process of total flavones in Semen cuscutae with macroporous resin. CNTF produces most, possibly all, of its effects by binding to a protein referred to as CNTF receptor alpha (CNTFRalpha). Lycopene and beta-carotene are two important nutritional components in tomato.

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Adherence to medication for the treatment of psychosis: rates and risk factors in an Ethiopian population. Neurological status was evaluated using the ASIA impairment classification and the motor score. We conclude that the working-ranges of both joints are under proprioceptive control of dorsal antennal hair fields. Plasmodium falciparum and Mycoplasma pneumoniae co-infection presenting with cerebral malaria manifesting orofacial dyskinesia and haemophagocytic lymphohistiocytosis.

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Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling. Certain sex differences have been revealed in the number, size and form of the superior mesenteric lymph nodes and their vessels. Improving local control in rectal cancer: radiation sensitizers or radiation dose? Field test of classical symmetric encryption with continuous variables quantum key distribution. Each pair consisted of two aliquots from the same semen specimen.

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However, in power spectral analysis of heart rate variability, the very-low-frequency component when standing was higher in TT carriers than in CC carriers, and TT and CT carriers had a significantly higher sympathetic nervous system (SNS) index and lower parasympathetic nervous system (PNS) index when standing than CC carriers. The overall level of PKC immunoreactivity was high at early postnatal ages (up to 6 weeks) and declined afterwards till adulthood. At 1 h, phospho-c-JUN and phospho-p38 were increased five- and two-fold, respectively. Most children with cancer have a tunnelled central venous catheter (CVC) inserted.

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Design, synthesis, and docking studies of quinazoline analogues bearing aryl semicarbazone scaffolds as potent EGFR inhibitors. intestinalis plerocercoids while there were significant positive (for Cu and Zn) and negative (for Fe and Mn) correlations between the quantity of heavy metals in bottom sediment and tissues of L. Unlike the situation described in previous reports on preventive trials, in this case Estonian women interested in participating in a PHT trial were not healthier than other women. The personality type of the groups involved in this study was determined, and the possible effect of personality type on learning style was investigated.

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The sinuses were excised in a vertical, elliptical fashion and the defect closed using a bilobed fasciocutanous flap. Ultrastructure of immature stages of Lucilia cuprina (Diptera: Calliphoridae) using scanning electron microscopy. These differences can produce alterations in the mechanical and neural control of upper airway collapsibility, which determine sleep apnea susceptibility. The clinical data of 2 infants with infantile glycogen storage disease type II (GSD II) from one pedigree were collected.

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Properties of the interaction of Arf-like protein 2 with PDEdelta. Deletion of three residues at each loop site produced protein molecules which retained considerable in vitro enzyme activity and in vivo repair function.

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The proposed model of controlled nonpenetrating blast in rats demonstrates the critical pathologic and biochemical signatures of blast brain injury that may be triggered by cerebrovascular responses, including blood-brain barrier disruption, glia responses, and neuroglial alterations. The most important rosiced crema rosacea treatment prognostic factors were the clinical grade at angiography or surgery, followed by the presence of preoperative spasm, hematoma or focal edema, elevated blood pressure on admission, time of interval from hemorrhage to surgery and age. Importance of instrumental studies for evaluating the degree of mitral stenosis However, the precise mechanism of apoptosis in such cancers has not been previously addressed. Effect of thoracic or diaphragmatic respiration on arterial blood gases in patients with chronic obstructive pulmonary disease