Circuvit and other coumarin anticoagulants act by inhibiting the synthesis of functional vitamin K-dependent coagulation factors II, VII, IX and X. Anticoagulants have no direct effect on an established thrombus, nor do they reverse ischaemic tissue damage. However, once thrombosis has occurred, anticoagulation therapy aims to prevent further clot progression and prevents secondary thromboembolic complications. The effective half-life of Circuvit ranges from 20 to 60 hours, with a mean of about 40 hours. The duration of effect is 2–5 days. The drug is completely absorbed after oral administration, and peak concentrations occur within 4 hours. The elimination of Circuvit is almost entirely by metabolism, with very little excreted unchanged in the urine and bile. Metabolism occurs mainly in the liver, involving the cytochrome P450, and in particular the CYP2C9, isoenzyme.
Other names for this medication:
Warfarin,
Coumadin,
Aldocumar,
Circuvit,
Coumadine,
Hemeran,
Jantoven,
Kovar,
Marevan,
Marivarin,
Martefarin,
Orfarin,
Panwarfin,
Simarc,
Warafin,
Warfarina,
Warfarine,
Warfin,
Warin,
Warlin,
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